J. Org. Chem 2021, 86, 5560- 5567
The key to the response is that the substrate replacement methanol derivative must contain either one or two aromatic aromatics of nitrogen and that the atoms and the α-carbon ion are in a co-operative position。
Reactable chorus consists of 2-- gills, 4-gills, and the right bits of gills, gills, gills, gills, gills。
Among the non-participatory substrates, the atoms and the α-carbon ion are not in a position of co-benefits, such as the methanol derivatives replaced by 3-thirty-thylene, the carbon in which the negative charge of the three-bit nitrogen and α-carbon is not on a co-convene transfer path, and the negative charge cannot be resonated through the ring to the nitrogen atom, and cannot stabilize the intermediate, so the reaction cannot occur。
Note: underlying red, not marked as a by-product of the system
Common response processes are as follows:
General production for the heterogenated alpha, and i2 (1. 2 equivaled), at 25 % of alpha-heterory-substantiated mercantilizationThe response was given by chomatography, prep-tlc, or prep-hplc to aford the dehydroxyproject.
