Zirunet lightning news, 14 may, as a key carrier of stem cell technology, the umbilical cord blood contains abundant stem blood cells and multiple cell types, not only as a key resource for treating blood and immune system diseases, but also as an indispensable link in the field of regenerative medicine, which is hailed as “the seed of life”。
However, negative rumours of umbilical blood have persisted, such as “payment for the blood of the umbilical cord in an institution and then finding that it is impossible to make a donation with a “child” “but there are not enough cells, there are no “to save” and so on, and biomedicine-related knowledge is relatively obscure and there are “information barriers”。
Is the cord blood really stored
So far, nearly 910,000 umbilical cord blood have been stored in shandong province's cord blood bank, 22,000 umbilical blood applications have been broken. There is growing interest in umbilical blood, but there are many questions about whether it is really stored
Whether or not umbilical blood is actually stored is a matter of interest to the relevant depositor, and some small biological companies in the market claim to be able to store it, but when the depositor was using it, the blood was lost. It is therefore important to shine their eyes when storing them, and to choose the umbilical blood bank that is formally legal and approved by the national health commission。
In shandong province, the blood bank is a special blood station under the supervision of the provincial board of health and health, established under the national unified plan and approved by the national board of health and health. In shandong province, every cord blood can be traced safely and applied safely. First, every umbilical cord that enters shandong province's cord blood bank is given a new id card - 128 yards. The isbt (international blood transfusion association) 128 barcode system, the only universal marking system for blood collection, processing and blood transfusions in the world, is currently the most widely applied barcode code for blood products. The 128-yard limit allows each cord blood to have its own “identity card” which guarantees the uniqueness of the cord blood and ensures that the cord identity information is safe and traceable. In addition, the stock of umbilical cords in shandong province can call our official guest service through protocol numbers, or through our regular live broadcasts, to check the location of their cord blood. We would also welcome all depositors to visit the umbilical blood bank to see the storage environment and state of their cord blood. Finally, our treasury applications are secure, with over 20,000 cord blood from the shandong province's cord bank clinically, and we also issue monthly bulletins about how long and when the cord blood collected in one of the hospitals treats any disease, as well as in shandong province's cord bank announcement。
What happens to donated cord blood
At present, the retention of umbilical cord blood is divided into donations and self-preservations, and can it be treated “in the same way” in relation to donated and self-sustained umbilical cord blood? What happens to donated cord blood
The umbilical blood is stored in “public bank” and “family bank”, which is often referred to as donations and self-reliance. The donation of umbilical blood, i. E. The donation of umbilical blood to a public bank for the benefit of patients in need of transplantation and for clinical research, will be vested in the umbilical blood bank and society as a whole. Self-deposited umbilical blood, which pays for technical services, is deposited into the family bank, and ownership and control of the umbilical is vested in the person responsible, primarily to safeguard the children and their families, and the umbilical bank and others are not entitled to use it. For shandong province's umbilical bank, we guarantee the quality of each cord blood, whether donated or stored, which is the bottom line that cannot be touched。
The process is the same, and both storage methods need to be collected, prepared and detected for storage. However, in terms of standards of access, the standards of entry for the two types of storage are different. The transplanted population of donated umbilical cord blood is the general public, and this type of transplant is an amphibious genetic transplant, which can have a significant exclusionary effect, so that a higher cell count is needed to achieve the optimal therapeutic effect, while the self-contained umbilical cord blood is relatively lower than its own cell count if it is used without an exclusionary reaction. In addition, the donation of umbilical cord blood is socially oriented, so that the standards for health screening are higher than those for self-generated umbilical blood。
Will the cord blood be stored? Which cord blood will be abandoned
Many years ago, umbilical blood was discarded as medical waste, but as the medical value of umbilical cord blood is excavated, it has now become a valuable biological resource and the retention of umbilical blood has become an option for a growing number of families. However, when umbilical blood arrives at the umbilical blood bank, it is not necessarily stored successfully, and there are cases of abandonment, such as the detection of unqualified umbilical blood, in which case, according to article 43 of the blood station management scheme, “the blood station must strictly enforce the provisions of the state concerning the disposal of blood by means of end-of-life and confidential disposal by blood donors who are exposed to risk of blood-borne disease”. At the same time, medical waste should be centrally disposed of in accordance with the regulations governing medical waste management。
How can the quality of cord blood storage be ensured
What special attention needs to be paid to umbilical blood as a biological cell resource that requires a specific transport and storage environment to ensure its quality and activity, throughout its storage and outlet applications? Will short exposure affect the application of cord blood
Blood from umbilical cords, from collection to transport, and the preparation, detection and release of post-mortem blood, is subject to strict requirements at every step, and the shandong cord blood bank has always insisted on quality control of the whole process, so that there will indeed be areas for special attention throughout the process. High-temperature exposure, for example, is the inevitable link between the preparation and storage of umbilical blood samples, e. G., the end of controlled cooling to the temporary storage tanks, the temporary storage tanks to the official storage tanks, the transplantation review or the exposure of samples to air from liquid nitrogen during the process. Strict control of high temperature exposure times is therefore another key to maintaining samples. The shandong cord blood bank is equipped with the lims information system, which, according to a high standard of fact certification, can record the time of exposure at any link, perform multiple validations, determine the time of exposure at high temperatures and record it in real time to ensure that each transfer is within control and that controlled and unavoidable exposure does not affect the clinical application of cord blood。
How can the temperature of cord blood be guaranteed
Oxygen blood is a highly active biological sample, stored under very strict storage conditions, and the liquid nitrogen bank that stores the blood of the umbilical cord is considered a “life bank” in industry. How does the shandong oxygen blood bank guarantee storage temperature
First, the safe storage of biological samples requires the maintenance of storage equipment. An imported, state-of-the-art, liquid nitrogen biocontainers are used in the storage tanks in shandong province. There are currently more than 400 tanks with a capacity of 1. 8 million, of which the maximum useful life of the tanks is nearly 20 years and their operation is stable. Second, the shandong cord blood bank has a high-quality monitoring system: the liquid nitrogen bank is equipped with an advanced liquid nitrogen tank monitoring system to monitor tank fluid levels, temperature changes in real time, and failure can provide timely warning and notification to staff for processing. The rehydration system can also be activated by a single key to ensure that the liquid level is maintained at normal levels. Thirdly, there is a very strict regulatory regime: liquid nitrogen bank staff need to ensure that tanks are inspected twice a day to record key data such as temperature, fluid level, etc.; regular liquid nitrogen spot measurements are performed to calibrate the fluid level; tanks are certified annually to ensure the thermogenic properties of the tanks; periodic metering and calibration are performed to ensure the accuracy of monitoring data。
How long can cord blood be frozen? Does it affect activity
So, how long can umbilical cord blood freeze in this 196°c environment, and how long will it affect its activity
In theory, umbilical cord blood can be permanently frozen. The umbilical cord is frozen in a liquid nitrogen environment of 196°c, the stem blood cells in deep cryogenic freezing are dormant, the enzymes in the cells are suppressed, and storage time from cryogenic biological analysis is unlimited. Available research data confirm that human umbilical cord blood remains highly active after more than 20 years of freezing. This is also confirmed by the sampled umbilical cord blood, which can still be stored for 20 years to meet clinical requirements. To further ensure the quality of the storage and cell activity of umbilical blood, every year the shandong cord blood bank carries out routine testing of frozen umbilical cord blood every five years (1st, 2nd, 3rd, 5th, 10th, 15th, 20th years after freezing), in accordance with the relevant provisions of the control procedures for the mass and stability of molybdenum stem cells. After multiple batches of sample results, it was confirmed that cord blood recovered to meet clinical application requirements。
Will the quality of the umbilical blood bank change as biotechnologies develop
Will the quality of umbilical blood change profoundly and positively in the context of this technological upgrading? How will this reshape our perception of and expectations for future health care
Developments in biotechnologies will undoubtedly lead to better and safer cord blood quality. It has been over 30 years since shandong province's umbilical blood bank was built, and from its inception to the present, equipment and technology are constantly being updated to move towards a higher level of systematic, scientific and intellectualization. For example, in the preparation chain, umbilical stem cell enrichment can be achieved by the use of full automatic separators, with accurate freezing volumes; the use of vertical infusion of cold-protected protective agents to protect stem cell activity more scientifically and effectively; the upgrading of cell count detection from the 3rd to the 5th class blood cell count; and the upgrading of detection equipment at the detection chain, from the original manual to semi-manual, to the present full automatic detection, which will minimize human operations, increase the efficiency of detection and reduce contamination of operators and samples from biological samples, which will guarantee high-quality storage of cord blood。
It is certain that future medical health will depend on the health of cell medicine and that the shandong cord blood bank will continue to pursue new discoveries and advances in cytology, providing more options and guarantees for the health of the general public。
How do we look at future applications of cord blood and stem cells
Before 1974, danish scientists had demonstrated that stem cells contained in cord blood were the same as bone marrow. In 1988, the world's first cord blood transplant succeeded in treating children suffering from van goni anaemia. The potential medical value of umbilical blood has been excavated and many research projects and harvests have been actively carried out in shandong province, so how do we look at future applications of umbilical blood and stem cells
Globally, umbilical blood has been used for the treatment of more than 80 diseases, over 8,500 clinical cases have been applied, and the number of clinical cases in the country has increased by more than 40,000, with over 22,000 cases in shandong province. Clinical experiments have confirmed that umbilical stem cell transplants and retrenchment, as advanced medical techniques, not only effectively treat some malignant neoplasms, diseases of the blood system, diseases of the immune system and diseases of the metabolic system, but also play an increasing role in the field of regenerative medicine, with enormous potential for the treatment of diseases such as cerebral palsy, autism, early ovary decay, cirrhosis of the liver, fracture of the bone, diabetes, in the brain, heart failure, and alzheimer's disease。
With the development of scientific technology, the entire stem cell industry will continue to tap its potential for application and will inevitably have more applications. In the future, shandong province's umbilical bank will take full advantage of the medical, academic, research and production systems, endeavouring to study the clinical application value of stem cells, promote efficient and high-quality stem cell industry development and better serve public health。
