In 2010, the red red network's "face killer". Source: new wave
In recent days, the news of the red fish killer's suicide with paraquat has touched your hearts。
At present meng, a “fish-killer”, has been admitted to jinan ziru hospital, and the situation remains less optimistic despite the various rescue measures taken by doctors. The director of the intoxication and occupational disease section of the hospital, zhuang, indicated to the east that the examination had revealed serious damage to meng's kidneys, which had reached the end of the urinary poisoning period and damage to the lungs。
This is not reminiscent of the even more spectacular news of the beginning of the year: a middle-aged man who had been unable to drink the paraquat he had bought on the internet for a while and who had been brought to the people's hospital in luizhou in time for his death 10 days later. During the treatment, doctors used various measures but were unable to return。
Of the two tragedies, the “principals” were paraquat. What is paraquat? It's herbicide. How does it kill people
Commercial paraquat
Paraquat, chemically called 1-1-dimethyl-4-4-hyena-ional ion salt (pq) (abbreviated in english), also known as grasspowder, gramoxone, balazi, was first developed by the british imperial chemical industry group (the world's largest pesticide enterprise first met syngenta ag). The first commercialized paraquat was marketed in the united kingdom in 1962 and quickly became the world's second largest herbicide with its high-efficiency weeding capacity. During the 1980s and 1990s, the production of paraquat was monopolized by foreign enterprises, and our country was totally import-dependent and expensive. In 1996, li dejiang, then deputy director of the shandong pesticides research institute (now director and party secretary of the shandong pesticides science institute), began the study of paraquat to address the problem. After many years of effort, the li german army managed to overcome the production difficulties of paraquat, and since then our country has been able to produce it on its own。
The father of chinese paraquat, li deokjun
Paraquat's weeding mechanism is its molecule (pq), which is highly soluble in water and allows rapid access to plant cells, which reach where cell synthetic nutrients are found — green leaves. The pq2+ ion can destroy the green leaf from two channels, starting with the electronic combination that should have been combined with the aridium aridium dioxin acid (nadp+) to produce pq+, then continuing to combine with o2 to generate hyperoxic free radicals, induce the production of lipid free radicals in plants, disassembly unsaturated fatty acids, damage to photocolytic membrane systems, which can also produce h2o2 and more toxic hydroxyl radicals oh, causing greater harm. Although there are enzymes protection systems in plants that can eliminate these free radicals, the free radicals are generated at a much faster rate than they are, and the poisons accumulate and eventually lead to plant deaths。
Map of green plant photosynthesis
Paraquat kills in a similar way, and when people take paraquat, it quickly enters blood from digestive tracts and is transported to various parts of the body, including our lungs. Pqs can be ingested in large quantities because of the presence of trans-shipment systems for metamines and the similar structures of pqs, which cannot be effectively identified by lung bubbles. The pq entering the lung, like the greening of the leaves, creates many free radicals, then reacts with oxygen molecules to produce ultraoxic free radicals, and by distorting the hyperoxidation enzymes into hydrogen peroxide, further developing the more toxic hydroxyl radicals, directly damaging the cell structure. In addition, the pq can inhibit the synthesis of intra-pulmonary fatty acids, depleting in large quantities a substance in the lung known as the reduced prototype accelerator ii (nadph), and many reactions relying on the involvement of nadph cannot be carried out, resulting in lung fibrosis, functional failure and patient death。
Paraquat to lung fibrosis ct
So, is there a cure for paraquat poisoning? Unfortunately, no. In addition, paraquat is produced at very low doses, with an oral lethality of about 30-40 mg/kg, and can also be killed by a solution of paraquat with long-term skin exposure above 5 mg per cent, and can cause lethal poisoning if the skin is broken. When paraquat is mistreated, it must not wait for medical attention, while reducing the intake of poisons, such as skin washing, promotion of urine and treatment with drugs such as anti-freedoms, which require serious blood dialysis. However, even so, according to statistics, there is little chance of survival for patients who have oral paraquat, and skin contact can be cured if treated in a timely manner。
Mr. Li, who had developed the paraquat production process, had also received the help of a large number of suicide victims or doctors each year since its successful development, and some questioned why he could not study the antidote since he had been able to do so. It makes no sense to speak for mr. Lee, who studied paraquat for the purpose of weeding, who had to drink it as poison and who didn't study the antidote. And later, in order to save as much as possible the lives of the suicide victim, mr. Li developed a new granular formulation, which would not dissolve immediately in the water, thus allowing enough time for the suicide victim to be calm, and it was still only for someone to wait for it to dissolve before drinking。
It is precisely because paraquat is so highly toxic that on 24 april 2012, the ministry of agriculture, the ministry of industry and information technology and the general directorate of state quality inspection issued proclamation no. 1745 on restrictive management measures against paraquat. With effect from 1 july 2014, the registration and production licences for paraquat water have been withdrawn, production has been discontinued, the export of water agents from the mother-producer enterprise has been maintained, the export of such agents has been permitted, and the domestic sale and use of such agents has ceased on 1 july 2016. However, since the weed-free effect of paraquat is so great that it has been sold through illegal channels, no matter what happens, except to urge the authorities to step up their efforts to investigate it, so that they do not lose their minds。
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