A reporter for the agricultural monument
Under the influence of the african swine plague, there is a growing awareness of the safety and control of pigs. In order to reduce hog stress and people's exposure to hogs, pig farms need to be streamlined in immunization procedures and operations. Mixed immune operations are produced and become hot in pig field applications. The operation of mixed immunization is not difficult, but it is difficult to properly organize the mixed immunization process and to determine the suitability of several vaccines for mixed immunization。
If a pig farm was in need of two vaccines at the same time, would it be possible to mix them at any time, as convenient as possible? Apparently not. Mixed immunization is not a mixture of needs, but is scientifically rigorous。
The combination of swine plague and hypocritical rabies is more accurate
Zhoubo, senior technical manager of the department of biological products of the chinese herd, described the two most important indicators of vaccine evaluation as safety and effectiveness. The results of the current validation of mixed immunization packages for products under the medium-pastoral flag have found that the combination of swine fever and pseudo-rabies has had a good effect, and that the combination of the two vaccines is easier to assess and more effective。
Why is the combination of swine plague and pseudo-rabies better evaluated? It was described that the end-product testing chain of vaccine production needed to be tested through safety tests and effectiveness tests, which generally validated vaccine effectiveness through anti-drug protection experiments, antigen concentration measurements, designated animal substitution tests, and neutral tests. The effectiveness of protection after immunization is more complex in the actual production process, with high demand for laboratory sites for anti-drug protection experiments, long cycles of assessment of production performance and a number of factors. In relative terms, pig plagues and pseudo-rabies can reflect their immunosuppressive effects at the middle and antibodies levels, facilitating the use of serophysics to evaluate their protective capacity, and therefore assessing results is reliable and convenient。
For the combination of some of the active seedlings and the active seedlings, the chorus suggests that after the mixing, some changes in the type of active seedlings may occur. There is no set of scientifically valid criteria for assessing the impact of such changes. “specificly, the use of live seedlings in the form of water or water or water-packed water is inherently fixed and may change in the form of a mixture of other vaccines. And the extent to which this change has had an impact on immunization effects is not yet scientifically sound, and users are concerned about the actual immune effects of this mix.” according to zhoubo, “this effect should not only be validated under laboratory conditions, but also, and more importantly, provide a viable assessment programme for pigfields so that users can also assess the effects of mixed immunization”
Thus, in terms of the reliability and ease of impact assessment, the combination of swine fever and pseudo-rabies is more likely to “see and feel.” “we have experimented with mixed immunization programmes, and various combinations have tried. The results of the combined immunisation experiment were found in swine plague and pseudo-rabies。
Mixing immunization is a prerequisite
Mixed immunization was also a prerequisite and could not be confused in order to avoid it, and zhoubo did not recommend forced neglect of immunization patterns and effects in order to reduce operations. “the intention and purpose of immunization is to protect animals from disease or disease, and if it is simple and blind, then the end is reversed.” zhoubo said。
There are deeper reasons behind the fact that mixed immunization is possible. There is a relationship between the vaccine itself, the virus itself, and the various production materials added to the vaccine, such as sorbents, protective agents, living agents, preservatives, etc., which must be matched enough to be removed. Zhoubo suggests that the chinese herd did not adjust the product itself because of the need to mix immunization, but rather that, based on a series of experimental tests of existing products, the safety and effectiveness of the mixed immunization mix of pigpest and pseudo-rabies products under the flag were found to be good as an option for use. “it is not intended to accommodate the transformation of the production process, but rather to provide such use options when the effects are tested, if required by the user.” zhoubo says。
Zhoubo indicated that, as a conglomerate, he had placed greater importance on corporate responsibility in a scientificly rigorous style. New programmes must be developed with scientifically sound certification before moving to the market. “the combination of vaccinations for swine plague and pseudo-rabies can be well assessed for safety and effectiveness. We have done a lot of tests, and users are assured that they will use our guidance. And impact assessments are replicable in the hands of users.”
The chinese swine plague and the hypocritical rabies can be mixed or separated according to demand
It was described that, in fact, a mixed immunization screening assessment had been carried out before the outbreak of the african swine plague. The early inspiration came from a line of users: “the pig farm felt that the pig plague was working well together, and it fed back on this phenomenon and made a plea to us to evaluate the effects of mixed immunization”. Zhoubo said that he had further conducted an impact assessment of the combination of swine fever and pseudo-rabies vaccine in march 2018. Following the outbreak of the african swine plague, pigs fields were more accepted and the promotion of mixed immunization methods became more popular。
So, what would be the effect of a combination of chinese pseudo-rabies and swine plague vaccines? Zhoubo indicated that the two were detected seven days after immunization, with a positive rate of 80-100 per cent for 14 days, 100 per cent for 28 days and within 10 per cent for dispersion; and 4-7 days after immunization, with strong protection。
How much can the combination of swine plague and pseudo-rabies immunization help to reduce the operation of pig farms? In the case of pigs, swine plagues and pseudo-rabies are generally exempted three times each, 6 doses of immunization are required if administered separately, and a combination of immunizations only takes 3 shots and halves the amount of operation; in the case of pigs, the issue of the timing of the exemption may be considered for one exemption if the time is closer to one week, or for two exemptions. To be precise, if the duration of the immunization procedure is closer, then it can be played together, and if the time overlaps completely, a total of two to three doses of immunization will be sufficient. Of course, there is no one-size-fits-all immunization procedure, and mixed immunizations are carried out according to the reality of the pig field. Zhoubo indicates that the error in the user's operation is due mainly to the failure to consider direct mixing of the immunization programme. And "the advantage of mixed immunization is that it can be played together or separately."
Pork plagues and pseudo-rabies are both frozen dry seedlings, each of which can be diluted into 1 ml or 2 ml and are simple to operate. Zhoubo suggested that if other seedlings were also immunized at the same time, if not validated and evaluated, they were proposed to be injected on a separate basis。
